منابع مشابه
Gene Regulation: The HSP70 Gene Jumps When Shocked
Limited chromosome mobility has been observed in mammalian interphase nuclei. Live imaging shows unidirectional and actin-dependent movement of HSP70 loci towards speckles upon heat shock, resulting in enhanced transcription. This adds further impetus to understanding compartmentalization of function in the nucleus.
متن کاملTranscription and post-transcriptional regulation of avian HSP70 gene expression.
Transient incubation of chicken lymphoblastoid (MSB) cells at elevated temperatures induces the synthesis of three heat shock proteins of 89,000 Da (HSP89), 70,000 Da (HSP70), and 23,000 Da (HSP23). We have examined the effects of heat shock on the transcription and post-transcriptional regulation of the chicken HSP70 and beta-actin genes. The rate of HSP70 transcription is rapidly induced by h...
متن کاملInducible Hsp70 in the Regulation of Cancer Cell Survival: Analysis of Chaperone Induction, Expression and Activity
Understanding the mechanisms that control stress is central to realize how cells respond to environmental and physiological insults. All the more important is to reveal how tumour cells withstand their harsher growth conditions and cope with drug-induced apoptosis, since resistance to chemotherapy is the foremost complication when curing cancer. Intensive research on tumour biology over the pas...
متن کاملPathways of allosteric regulation in Hsp70 chaperones
Central to the protein folding activity of Hsp70 chaperones is their ability to interact with protein substrates in an ATP-controlled manner, which relies on allosteric regulation between their nucleotide-binding (NBD) and substrate-binding domains (SBD). Here we dissect this mechanism by analysing mutant variants of the Escherichia coli Hsp70 DnaK blocked at distinct steps of allosteric commun...
متن کاملHsp70 gene association with nuclear speckles is Hsp70 promoter specific
Many mammalian genes localize near nuclear speckles, nuclear bodies enriched in ribonucleic acid-processing factors. In this paper, we dissect cis-elements required for nuclear speckle association of the heat shock protein 70 (Hsp70) locus. We show that speckle association is a general property of Hsp70 bacterial artificial chromosome transgenes, independent of the chromosome integration site, ...
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ژورنال
عنوان ژورنال: Cell Stress and Chaperones
سال: 2011
ISSN: 1355-8145,1466-1268
DOI: 10.1007/s12192-011-0290-6